John Karanicolas

Assistant Professor of Molecular Biosciences
Primary office:

Dr. Karanicolas is an expert at using structure-based methods to modulate protein function using small-molecules. His lab is exploring two parallel paths towards this overarching goal: the first is re-engineering proteins so that a small-molecule can be used to "turn on" function, and the second is identifying small-molecules that naturally complement and occlude a protein surface to "turn off" function. They work to apply these tools to understand how specific protein interactions are responsible for normal and aberrant signal transduction in cells.

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