(Ph.D., Johns Hopkins University) Dr. Timmons' research focuses on a genetic technology and mechanism known as RNA interference (RNAi). RNAi technology utilizes double-stranded RNA to shut down the function of specific genes within cells. The Timmons lab has discovered that ABC transporter proteins, which often contribute to drug-resistance in cancer cells, play a role in RNAi, and the ABC transporters also protect DNA against invading genome parasites. These findings may provide clues to the etiology of drug-resistant cancers and allow for new therapeutic strategies. In collaboration with the Medical School of Hannover, Germany, the Timmons lab is also investigating potentially new signaling pathways in cells that have been implicated in heart failure and cancer.